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Our results demonstrated that GSH-related Nrf2 signaling pathway can be pharmacologically manipulated by AZI, which may provide new possibilities in the treatment of airway epithelium damage-related respiratory diseases induced by CS, such as COPD

Clinical group The clinical group consists of all smokers who attended a smoking cessation clinic in a comprehensive cancer center located in LHospitalet de Llobregat, Barcelona, Spain, between 2010 and 2017 (n=579)

Tobacco-related illnesses cancer, heart disease, and lung disease are among the most common causes of death in individuals with behavioral health conditions

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While a smooth and slight upward curve was observed with increasing daily consumption grew after multivariate adjustment (Figure 1C)