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Then, due to the proximity that macrophages and tumor cells reside in, interactions between VCAM-1 and the 4 integrins are promoted, which recruit Ezrin, a cytoplasmic adaptor protein that links the actin cytoskeleton to the cytoplasmic tail of VCAM-1, and ultimately results in tyrosine phosphorylation of Ezrin

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The condition is unbearable and can take up to a month or even years to cure