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Blood 1 to 3 days [1] Saliva 1 to 3 days [1] Urine up to 8 weeks (cotinine levels) [2] Hair follicles possibly weeks to months [3] While hair follicles and urine can retain nicotine and cotinine longer, you may want to take a blood test if you wish to know how much of these chemicals are in your system

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It can also negatively affect male fertility

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Then there is the risk of becoming addicted to nicotine, Coykendall said, which leads to smoking