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"While the study was focused on adults, there are data that have been published, and forthcoming as well, that shows that an appreciable proportion of teens also use nicotine pouches at rates that are higher than what we found for adults," Leventhal said

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The CCL5-CCR1/CCR5 axis maintains crosstalk between BC cells and TAMs and VCAM-1 upregulation increases the binding of TAMs and BC cells during infiltration, which enhances the survival rate of metastatic BC cells during lung colonization

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doi: 10.1093/toxsci/kft107 167