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Respiratory irritation and the bronchial constriction from a propylene glycol aerosol raise concerns about harm to people with asthma and chronic obstructive pulmonary disease, but one small study reports no harm but rather benefit when users quit smoking or smoke fewer cigarettes per day. Keep in mind, however, that the research here is still early, and this conclusion on e-cigarettes could change once tens of thousands of people and not just dozens or hundreds have been studied

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Further validation of a cigarette purchase task for assessing the relative reinforcing efficacy of nicotine in college smokers

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Biological Causes of Tobacco Addiction The biological causes of tobacco addiction include nicotines effect on brain chemistry, genetic predisposition, and neuroadaptation