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The water cools the smoke and can trap a small amount of ash/particulates, making each inhale feel smoother

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Synapse 44:252253 Paterson NE, Semenova S, Gasparini F, Markou A (2003) The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice

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Regulation of lung immunity by dendritic cells: Implications for asthma, chronic obstructive pulmonary disease and infectious disease