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Because it hasn't gone through rigorous clinical trials, we just don't know what a safe dose is, what the short-term side effects are, or what the long-term health consequences could be

Per serving

Creatines protective activity against radicals also points to its role as an antioxidant [47]

All the remaining patients (n=45) were evaluated for luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2), progesterone (P), androstenedione (A), testosterone (T), insulin, C peptide, total cholesterol, HDL, LDL, glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) concentrations

Rising hunger, waist growth, weight gain above about 2 lb per month, persistent heart-rate elevation, or declining strength indicate that the lower dose is not maintaining the prior response

What about timing semaglutide with methylcobalamin B12