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In turn, ROS and pro-inflammatory mediators such as IL-6 and IFN have been reported to increase chemotherapy resistance by up-regulating anti-apoptotic genes, stimulating stemness, increasing repair of damaged DNA, and increasing drug efflux 29,41,63

[71] In general, mesothelioma is characterized by loss of function in tumor suppressor genes, rather than by an overexpression or gain of function in oncogenes