timeline of tobacco use History History and types of tobacco

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Changes in the spontaneous tonic firing of VTA DA neurons, as a consequence of repetitive drug use, can indeed alter the subjective value assigned to available rewards 21 , as well as the motivational salience of the drug or of drug-predicting cues 24 , influencing decisions about which reward to pursue 25

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However, this study was criticized for "retrospective bias" in asking subjects to accurately remember, and be willing to tell, details of their lifestyles

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