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Of course, there are many reasons that a cat might lose his appetite and weight, from dental disease to kidney disease (perhaps not supported by bloodwork in your case thus far) to various forms of gastrointestinal disease, so the most important thing is for you to continue to work with your veterinarian to rule out the more common and well understood causes of these signs in cats and to address any that may be identified

Method of Consumption Smoking or vaping tends to clear out of your system faster than edibles, which take longer to digest and break down

[Ibn Abidin, Radd al-Muhtar] I would like you to go through the valuable answers and links below

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The Health Consequences of Smoking 50 Years of Progress: A Report of the Surgeon General

Setbacks may occur, but they are part of the journey towards a healthier lifestyle