A combination therapy of short-acting (nicotine gum, lozenge, inhaler, or spray) with long-acting (nicotine patch or bupropion SR) can be used in the case of patients who remain refractory to monotherapy ( 87 )
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In many parts of the world, including the Middle East, the portfolio is owned by a subsidiary of Philip Morris International, while in others it is managed by Rothmans, Benson & Hedges Inc
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