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doi:10.1136/thx.2008.102947

Smoking addiction has two components the chemical dependency on nicotine and the behavioral habit (hand-to-mouth motion, the inhale, the social ritual)

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This is cyclised by a carbonyl-ene-reaction initiated by zinc bromide to isopulegol, which is then hydrogenated to give pure (1 R ,2 S ,5 R )-menthol

In one case, agents for the Bureau of Alcohol, Tobacco, Firearms and Explosives sold $15 million in cigarettes and later turned over $4.9 million in profits from the sales to a confidential informant even though the agency did not properly account for the transaction