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Melanin is the pigment that gives skin, hair, and eyes their color

As an effect of ROS on the central nervous system (CNS), which has a high lipid content and high oxygen consumption, the oxidative agents promote lipid peroxidation, leading to membrane fluid loss, suppressing membrane potential, and increasing the accumulation of ions, particularly Ca 2+

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Compared to both single alterations, the combination of DHODH deletion and LDHB silencing significantly increased mitochondrial lipid peroxidation levels (Fig

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