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Start at two to three applications per week and build up gradually

Krehelova A, Kovarikova V, Domorakova I, et al

Clinicians working with patients who have compromised gut barrier function, often framed as increased intestinal permeability or "leaky gut," sometimes extend oral BPC-157 protocols to ten to twelve weeks given the chronicity of the underlying pathology

Evidence is promising but limited

A Nature Scientific Reports 2016 study showed GHK-Cu had no cytotoxicity to human keratinocytes at concentrations up to 5,800 M over 72 hours and did NOT induce inflammatory biomarkers (IL-1, IL-8, HSPA1A, FOSL1) unlike other copper compounds, concluding GHK-Cu has a low potential of inducing skin irritation

This protein is essential for fatty acid oxidation, a multistep process that breaks down (metabolizes) fats and converts them into energy