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For instance, pirfenidone inhibits TGF--induced Smad3, p38, and protein kinase B (Akt) phosphorylation, thereby suppressing fibroblast proliferation and collagen production (146)

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While this proposal is controversial [34], we consider that nitrosamines should be regularly measured as part of the regulatory tasks of health agencies across the world to better inform consumers about the health risks of smoking

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