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In 2024, percentages ranged from 0.2 percent of adolescents aged 12 to 17 (or 57,000 people) to 1.0 percent of adults aged 26 or older (or 2.2 million people) ( Tables A.11B and A.13B )

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Long-term nicotine use affects digestive health through multiple mechanisms: Altering gut microbiome composition and diversity Changing blood flow patterns to digestive organs Modifying nervous system signaling pathways Creating dependency for normal bowel function For people with Crohn's disease, continuing nicotine use can be particularly harmful

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