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A key assumption of permutation tests is exchangeability and therefore, we permuted the exposure conditional on the subject (e.g., exposure was permuted on the HBEC values from a single donor, not across donors) and kept the numbers of permuted observations under each condition the same as the observed results

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Public health officials say this is concerning, because the products can have as much or more of the highly-addictive nicotine found in traditional cigarettes

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From now, you are embarking on a journey to go smoke-free' and it may take you a day, it may take you longer, but you CAN make the switch completely