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We included studies that used non-users of both vaping devices and conventional cigarettes as a comparison group and those that used a pre- and post-design in which individuals acted as their own controls

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For example, overactivation of the RAAS (Singh and Mehta, 2003) and insulin resistance (Ormazabal et al., 2018) alter systemic lipid metabolism, leading to the development of atherogenic dyslipidemia