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(Her et al., 2009) have shown that HDAC inhibitors, namely TSA, sodium butyrate, and VPA, promoted differentiation of rat C6 glioma cells by producing neuroactive 5-reduce neurosteroid, which stimulated expression of serotonin stimulated brain derived neurotrophic factor transcription

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However, comprehensive long-term safety data remains limited, particularly regarding extended use over months or years

Use with caution in pregnant animals

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