PMID 23755725
At least in rats, they've shown, or was it mice, I think it might have been rats, but multiple studies showing that it's released from the cold in the brain
doi: 10.1186/s12885-023-11589-5 125 ZhangLHobeikaCSKhabibullinDYuDFilippakisHAlchoueiryMet al
16, 10391046.10.1094/MPMI.2003.16.11.1039 31 MatamorosM
Molecular docking studies By selecting the co-crystallized ligand located at the proteins active site ( 31.02, 21.89, and 30.09), the receptor grid generation panel revealed the x , y , and z coordinates automatically
34 Our studies focused only on the effects of TGF 1 on claudin-5 expression and demonstrated that treatment of bEnd.3 cells with rTGF 1 downregulated claudin-5 and led to the translocation of this protein from the cell membrane to the cytosol