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As for the secondary outcome measures of gastrocnemius muscle mass and flexion foot contracture, there was a significant decrease in muscle mass seen in the right hind limb that underwent sciatic nerve transection, in comparison to the left hind limb that was not operated on

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But 23% is still a meaningful step up from what semaglutide (Wegovy) achieves on its own, where the average tends to land around 14 to 15%