These metals steal sulfur groups from enzymes, protein compounds and/or peptides such as glutathione S-transferase (GST), an enzyme dependent on glutathione that studies have shown provides protection against the spread of cancer cells
One of it's main roles is to remove free radicals from the body
Optimal phase II and III detoxification requires the activation of the cellular master switch Nrf2.12 Nrf2 regulates over 500 genes involved in detoxification
[1] The experimental design of that early work is itself instructive for the systemic question
Effects of Diclofenac, L-NAME, L-Arginine, and Pentadecapeptide BPC 157 on Gastrointestinal, Liver, and Brain Lesions, Failed Anastomosis, and Intestinal Adaptation Deterioration in 24 hour-Short-Bowel Rats
Both are considered doping substances by international sports authorities and are banned by the World Anti-Doping Agency along with MOTs-C, an exercise mimetic