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Mathematical Framework for Human Equivalent Dose The human equivalent dose (HED) formula is: HED (mg/kg) = Animal dose (mg/kg) (Animal Km / Human Km) Standard Km constants used in pharmacological scaling are: Rat Km = 6 Human Km = 37 To illustrate: If a rat study administers 10 mcg/kg, convert micrograms to milligrams: 10 mcg = 0.01 mg HED = 0.01 (6 / 37) HED 0.00162 mg/kg HED 1.62 mcg/kg For a 70 kg individual: 70 1.62 mcg 113 mcg This represents a mathematically scaled equivalent exposurenot a prescription

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CAS Number 137525-51-0 Molecular Weight 1419.53 g/mol Molecular Formula CHNO Class Gastric Pentadecapeptide Research context

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Djakovic.z, Djakovic.I, Cesarec.V, Madzarac.G, Becejac.T, Zukanovic.G, Drmic.D, Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME

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