J Biol Chem 281, 1077810785
L- 1030
Glutathione is a powerful tripeptide found in every cell, known for its role in neutralizing free radicals and recycling other antioxidants like vitamins C and E
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Krauth-Siegel et al., studied the Y197S variant of GR and concluded the diminished accumulation of FAD-NADPH charge transfer and the overall decrease in the rate constants observed for reduction were evidence of Y197 directly participating in the flavin reduction event (Krauth-Siegel et al., 1998)