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36 In addition, it has been shown that the imbalance between oxidants and antioxidants resulting from exposure to tobacco smoke leads to oxidative stress, increased mucosal inflammation, enhanced release of IL-8, IL-6, and TNF and to the recruitment of macrophages and neutrophils

It also means that a US or EU buyer is looking at a product that is not FDA-approved for aesthetic use

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Other peptides signal more effectively