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10.1007/s00204-019-02409-6 2 AllamV.PatelV

As for the role that caffeine has in the purported benefits of the coffee enema, drinking coffee is a far more effective method for increasing the amount of caffeine in your blood (and hence causing vasodilation to potentially send toxins from the blood into the colon, or causing increased bile acid secretion to potentially facilitate liver detoxification) compared to administering it at the other end

The peptide itself only accounts for part of the equation

Bertoncini-Silva C, Vlad A, Ricciarelli R, Giacomo Fassini P, Suen VMM, Zingg J-M (2024) Enhancing the bioavailability and bioactivity of curcumin for disease prevention and treatment

10.1097/MD.0000000000027522 34 JiangX.StockwellB

(eds) Joint Function Preservation: a Focus on the Osteochondral Unit (Springer International Publishing, 2022)