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Clinical trials show average weight loss of 15-22.5% of body weight over 72 weeks with tirzepatide alone

Collagen synthesis genes (COL1A1, COL3A1) are upregulated, while collagen-degrading matrix metalloproteinases (MMP-2, MMP-9) are simultaneously downregulated

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Heddleston JM, Li Z, McLendon RE, Hjelmeland AB, Rich JN

Aqueous solubility facilitates transport within the blood and excretion via the kidney, while a lipophilic chelator may exhibit greater penetration of cellular membranes (including those within the central nervous system) to chelate intracellular elements

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