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By modulating pain pathways and reducing inflammation, BPC-157 may help alleviate abdominal pain and cramping associated with IBS, leading to improved comfort and quality of life

D., Mattamal, M

9 , ra115 (2016)

JAMA Pediatr

4 A 2025 mechanistic study using RAMP1/RAMP3 knockout mice demonstrated this dependence directly: cagrilintide activated area postrema neurons and reduced body weight in wild-type animals but had essentially no effect in mice lacking these receptors, pinning its action to the AMY and AMY subtypes in the hindbrain

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