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Notably, these studies demonstrated metformins pleiotropic effects on several molecular and metabolic pathways, such as androgen signaling, cell cycle, and cellular bioenergetics
Jiang X, Xin H, Ren Q, Gu J, Zhu L, Du F, et al
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While such an arrangement could be achieved by small disulfides such as HEDS, bulky protein substrates might cause significant deviations from this reaction geometry (Fig
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