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doi: 10.1038/s41577-019-0240-6

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Because the induction of these genes is only transient, the glutamate consumption is likely to be buffered by steady-state central carbon metabolism, under which glucose and glutamate fuel mitochondria to support cellular bioenergetic demands (Fig

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Cagrilintide represents the modern re-engineering of that idea: a lipidated, structurally modified amylin analogue stable enough for once-weekly dosing and active at both the amylin and calcitonin receptors

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