One of the most common physiological changes seen is the depletion of the bodys most powerful antioxidant, reduced glutathione
Because autophagy may serve as a protective mechanism for CLL cells (36), we then tested CB-839 in combination with the autophagy inhibitor chloroquine at a concentration of 50 M ( Supplemental Figure 5 )
Glutathione is generally safe but should be avoided in pregnancy or by individuals with serious health conditions
Hoogeveen EK, Kostense PJ, Jakobs C, Dekker JM, Nijpels G, Heine RJ, Bouter LM, and Stehouwer CD (2000)
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