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The scheme of typical glucuronidation reactions is shown in Figure 1

2 Mechanisms of OS-induced nerve damage In the context of DN, OS contributes to oxidase activation, mitochondrial dysfunction, apoptosis, inflammation, and endoplasmic reticulum (ER) stress, which are critical in the pathogenesis of nerve injury (Figure 1)

Quesada-Vzquez et al

1 Registered Clinical Trials Research data sourced from ClinicalTrials.gov

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Continuous variables, namely age and body weight, were categorized using clinically relevant thresholds to facilitate regression analyses