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Sandalova, E., Li, H., Guan, L., Raj, S., Lim, T., Tian, E., Kennedy, B., & Maier, A

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In a pilot trial, DFP orally administered 15 mg/kg twice daily showed reduced iron deposition in the globus pallidus in patients with pantothenate kinase-associated neurodegeneration (PKAN), a rare disease characterized by neurodegeneration with brain iron accumulation (NBIA) (Uzungil et al., 2022)

These four protein complexes are the NADH:ubiquinone oxidoreductase complex (complex I of the respiratory chain), the succinate dehydrogenase complex (complex II of the respiratory chain), CDP-diacylglycerolinositol 3-phosphatidyltransferase (CDIPT), and solute carrier family 16 member 1 (SLC16A1)

Reconstitution requirements add complexity