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Cellular Senescence and Aging Research Senescent cells accumulate naturally with age and contribute to: Chronic inflammation Tissue dysfunction Reduced regenerative capacity Biological aging Research involving FOXO4-DRI investigates its potential role in selectively clearing these dysfunctional cells to support healthier tissue environments

Targeting this axis with resveratrol provides a promising combinatorial strategy to overcome chemoresistance

Jabbour HN (2009) Vascular function in female reproduction

Once inside cells and tissues, ALA transforms into dihydrolipoic acid (DHLA), an even stronger antioxidant with the power to neutralize reactive oxygen species while simultaneously chelating transition metals, thereby protecting membrane lipid peroxidation or protein damage [204,205]

Gastroenterology 159 , 849863 (2020)