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Group II receptors (mGluR2/mGluR3) and Group III receptors (mGluR4 and mGluR6mGluR8) are coupled to G q proteins and inhibit adenylate cyclase

pH-cleavable acetal and ketal linkages have been incorporated into the polymer backbone and used as a junction between hydrophobic and hydrophilic parts

while an intervention study of smoking would not be feasible, a retrospective study of cigarette smoking in PD indicates no effect on the progression of established disease 58

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