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About this article Cite this article Fan, Y., Zang, D., Wang, T

Decreased synthetic capacity underlies the age-associated decline in glutathione content in Fisher 344 rats

In conditions characterized by chronic immune dysregulation, such as autoimmunity in Long COVID, the failure of this delicate S-glutathionylation process contributes to sustained tissue damage and cellular miscommunication

7.2 Actionable research recommendations See Table 3

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Treated mice showed improved Morris water maze performance reduced escape latency emerging across roughly days 45 of the training protocol alongside increased synaptophysin and reduced inflammatory markers (IL-1, TNF-), reportedly via PI3K/AKT signaling