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[114] (See Endogenous opiate precursor theory) After a preliminary 1998 study of three children with autism treated with secretin infusion reported improved GI function and dramatic improvement in behavior, many parents sought secretin treatment and a black market for the hormone developed quickly

This is a subtle but devastating failure point in research, leading to inconsistent or null results that are impossible to troubleshoot

CDC.gov

XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification

These results are often better than what people see with diet and exercise alone or some other medications

"Prenatal risk factors for autism: comprehensive meta-analysis"