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B12 may be injected into a muscle or under the skin at 100 mcg daily for a week, every other day for another week, and then every three or four days for a month

These reasons include DNA damage, oxidative stress, or the shortening of telomeres

Giving them more frequently than the established schedule is a form of over-treatment that is not supported by evidence and can strain healthcare resources (nurses time, clinic space, and medication supplies)

DOI: 10.1038/s41598-017-01078-8 Casarini L & Simoni M (2018) Two Hormones for One Receptor: Evolution, Biochemistry, Actions and Pathophysiology of LH and hCG Endocr Rev 39(5):549592

When side effects occur, they're typically mild and short-lived