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We review astroglial pathophysiology across the spectrum of human CNS diseases and disorders, including neurotrauma, stroke, neuroinfection, autoimmune attack and epilepsy, as well as neurodevelopmental, neurodegenerative, metabolic and neuropsychiatric disorders

Retatrutide introduces a new safety signal, dysesthesia, present in one-fifth of patients at 12 mg, linked to glucagon activity

In different cell types, such as endothelial phagocytes, smooth muscle cells, fibroblasts, and glial cells, TNF- and ILs upregulate PTX3 transcription and are involved in atherogenesis

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Alzheimers disease: a global challenge for the 21st century