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The other thing worth setting expectations on: outcomes vary

Cell pellets of HEK293 or these cells transiently expressing FSP1 or other NAD(P)H-dependent oxidoreductases were resuspended in TBS buffer (50 mM Tris-HCl, pH 7.6, 150 mM NaCl, 1x protease inhibitor cocktail) and lysed by sonication on ice

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Schedule Once weekly for both compounds

Oakley AJ, Lo Bello M, Battistoni A, Ricci G, Rossjohn J, Villar HO et al

4 and 5), and the combination of the IGF-1R inhibitor and MEK inhibitor significantly suppressed cell growth and induced cell death in both cultured cells and mice (Figs