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Along with complimenting each other, the combination also leads to reduced drug resistance which is generally seen with monotherapy [260, 261]

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Additionally, in lung cancer cells and osteosarcoma cells, LDHA phosphorylation at serine 196 by ULK1 promotes lactate generation, which subsequently induces PIK3C3 and Vps34 lactylation at lysine 356 and lysine 781, respectively

16, Sonthalia, Sidharth, et al

Samples were grounded in solution comprising of thiobarbituric acid (TBA 0.25%) prepared in trichloroacetic acid (TCA 10%) followed by heating them at 95 C then cooled on ice and centrifuged for 10 min at 10,000 g