In murine models of doxorubicin (DOX) and ischemia/reperfusion (I/R)-induced cardiomyopathy, administering DOX to mice induced cardiomyopathy with a rapid, systemic accumulation of non-heme iron via heme degradation by Nrf2-mediated upregulation of HO-1, which effect was abolished in Nrf2-deficient mice (van Raaij et al., 2018)
10.4049/jimmunol.0802971 30 Martin-SanchezD.Ruiz-AndresO.PovedaJ.CarrascoS.Cannata-OrtizP.Sanchez-NioM
Additional information Communicated by: Henner Hollert Rights and permissions About this article Cite this article Hellou, J., Ross, N.W
Vegan Negatives of Cyanocobalamin It is potentially harmful in large doses if users are smokers or to those with existing high levels of cyanide exposure
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