Most people find them virtually painless
Bacteriostatic water has been established as a safe and efficient reagent for the reconstitution of peptides, however there are some possible caveats to consider
Ceramides help strengthen the skin barrier, whilst gentle exfoliating agents like lactic acid can help remove dead skin cells for better product penetration
Medical Biochemistry (Second Edition): Academic Press
Anything beyond that should only be done under medical supervision, especially if you have thyroid, kidney, or liver conditions
Use a hand mirror to check buttocks, genital area, lower and upper back, and the back of neck and ears (it may be easier to look at the back in a wall mirror using a hand mirror)