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In addition, we conduct a bibliometric analysis of studies investigating the relationship among ferroptosis, the gut microbiota, and CKD, aiming to provide a more comprehensive and in-depth understanding of the mechanisms of CKD progression and potential therapeutic approaches for associated complications

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Future directions Future research should aim to elucidate the molecular and cellular pathways by which tobacco smoke and vaping constituents drive liver injury, immune dysregulation, and carcinogenesis

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