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In vitro , Ras palmitoylation promotes stress kinase activation through the Tiam1-Rac1-Nox2 signaling module, leading to mitochondrial dysfunction and endothelial cell apoptosis that drive the progression of diabetic retinopathy, whereas 2-BP is able to inhibit high-glucose-induced p38 MAPK activation and mitochondrial DNA damage, and targeted intervention of these pathways may provide a new strategy for the early control and prevention of diabetic vision loss (235)

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For both strategies, a combination of 1 h open tube incubation followed by 2 h closed tube was found best for oxidation

Youssef, Ain Shams University, Egypt Reviewed by Zhiwen Luo, Fudan University, China Roman A

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