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Finally, we identify key knowledge gaps, including standardisation of manufacturing protocols, optimisation of dosing and timing relative to chemotherapy, and development of harmonised endocrine and fertility endpoints for forthcoming randomised trials

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This design resulted in one group of children who had topical glutathione and oral DMSA challenge followed by continued administration of DMSA and a second group of participants who underwent a single round of DMSA challenge without topical glutathione and who subsequently did not receive any further chelation

These effects can further reduce neuron damage and apoptosis