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Key findings: Adults using melatonin for 1+ year were more likely to develop heart failure than non-users Those taking melatonin long-term were 3.5 times more likely to be hospitalized for heart failure All-cause mortality risk was also elevated in the long-term melatonin group Critical context: This study is observational and has not yet been peer-reviewed

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RoseRASellanMSimpsonJAIzaddoustdarFCifelliCPanamaBKet alIron overload decreases Cav1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation

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doi: 10.2147/CLEP.S167128 79 DaiMXuYGongGZhangY