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doi:10.1016/j.lfs.2019.117139 Deng M, Zhang Q, Yan L, et al

Early and smaller studies suggested effects on fat metabolism and body fat distribution, but larger obesity trials did not show a robust, clinically meaningful weight loss outcome on their own

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The exceptional in vitro potency is attributed to its mechanism of acting as an allosteric potentiator of HGF binding to c-Met (amplifying an endogenous signal), which produces non-linear dose-response curves