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Ablation of Shank3 alleviates cardiac dysfunction in aging mice by promoting CaMKII activation and Parkin-mediated mitophagy

This is often easier to measure accurately

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A greater understanding of the mechanisms responsible for the clinical and metabolic effects of the poly-agonists, the balance of receptor agonism needed for optimal effects, and the heterogeneity in response among individual patients and different patient populations will be important to guide future drug development and clinical application

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