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Plasma metabolomics analysis showed that LC differed from the R and HC groups

GNDs exerted a selective inhibition of NO generation without interfering with the accumulation of pro-inflammatory agents by disrupting the synthesis of inducible NO synthase in activated macrophages through up-regulation of eIF2 phosphorylation levels, without disturbing Fe homeostasis (Zhang et al., 2022)

This mechanism provides a unifying explanation for UPS impairment in both familial and sporadic NDDs

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Quantification was performed using electrospray in the positive mode with the spray voltage of 3500 V